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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク HULC (gene) ： ウィキペディア英語版 HULC (gene) In molecular biology, ''H''ighly ''U''p-regulated in ''L''iver ''C''ancer (non-protein coding), also known as HULC, is a long non-coding RNA. It was first identified in hepatocellular carcinoma, and is also expressed in colorectal carcinomas that metastasise to the liver. It may have a role in the post-transcriptional regulation of gene expression.〔 It downregulates the expression of several microRNAs, including miR-372. Expression of HULC is upregulated by CREB, there is a CREB-binding site in the promoter of HULC. miR-372 represses translation of the kinase PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB. PRKACB activates CREB by phosphorylation, therefore leading to increased expression of HULC.〔 ==See also== * Long noncoding RNA 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HULC (gene)」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.